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Amino acids
This blog emphasizes amino acids' critical roles in biologics' production processes, particularly upstream and downstream. Amino acids are highlighted as essential components in culture media during the upstream process, influencing cell proliferation and maximum cell density in cell culture. In the downstream process, amino acids serve various functions such as stabilizers, antioxidants, and buffering agents during the extraction and purification.
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Biological buffer applications
Biological buffers are organic substances that maintain a solution's pH close to constant. They are used throughout the manufacturing hashtag#process of hashtag#biologics, mainly in upstream (USP) and downstream (DSP) processes. Buffers are utilized in USP because of their ability to help keep culture pH within a certain range and optimize conditions for cell growth.
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Trehalose
Trehalose is a powerful cryoprotectant that enables cells or tissues to be preserved while maintaining their viability and functionality over long periods of cryopreservation. It is also an essential excipient in the freeze-drying process for biological products.
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Mannitol and sorbitol for biological drugs formulation
In this blog, we discuss the benefits of using polyols as excipients and how they can be used to stabilize biological APIs. We also cover the leading polyols consumed, their solubility in aqueous solutions, and the various functions they serve in formulations. Additionally, we provide information on other products that can be mixed with polyols to create the perfect formulation.
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